D. M. Carone

Human XIST RNA acts early to condense architecture which facilitates A-repeat density-dependent initiation of gene silencing

This study shows XIST RNA condenses chromosome architecture early, which is necessary for gene silencing initiation, and that A-repeat density is critical for this process.

Ectopic expression of pericentric HSATII RNA results in nuclear RNA accumulation, MeCP2 recruitment, and cell division defects

This study shows that ectopic HSATII RNA expression in normal cells causes nuclear RNA accumulation, MeCP2 recruitment, and cell division defects similar to those in cancer cells.