Role Of The C-C Motif Chemokine Ligand 5 (CCL5) And Its Receptor, C-C Motif Chemokine Receptor 5 (CCR5) In The Genesis Of Aldosterone-induced Hypertension, Vascular Dysfunction, And End-organ Damage
R. M. Costa, D. M. Cerqueira, A. Bruder do Nascimento, J. V. Alves, W. M. C. Awata, S. Singh, A. Kufner, E. Cifuentes-Pagano, P. J. Pagano, J. Ho, T. Bruder-Nascimento
This study shows that CCL5/CCR5 contributes to aldosterone-induced hypertension, vascular injury, and renal damage by promoting inflammation and oxidative stress.
bioRxiv · Sep 22, 2023 · PreprintPharmacology & Toxicology