R. M. Costa

Adjusted vascular contractility relies on integrity of progranulin pathway: Insights into mitochondrial function

This study shows that progranulin (PGRN) is essential for vascular contractility by regulating mitochondrial function, mitophagy, and redox signaling in vascular smooth muscle cells.

Role Of The C-C Motif Chemokine Ligand 5 (CCL5) And Its Receptor, C-C Motif Chemokine Receptor 5 (CCR5) In The Genesis Of Aldosterone-induced Hypertension, Vascular Dysfunction, And End-organ Damage

This study shows that CCL5/CCR5 contributes to aldosterone-induced hypertension, vascular injury, and renal damage by promoting inflammation and oxidative stress.

Vascular injury associated with ethanol intake is driven by AT1 receptor and mitochondrial dysfunction.

This study shows ethanol-induced vascular dysfunction is mediated by AT1 receptor activation and mitochondrial dysfunction, which can be mitigated by losartan.

NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration

This study shows that high testosterone increases NOX4 in endothelial cells, boosting H2O2 production to counteract testosterone-induced endothelial dysfunction and impaired migration.

Suppressed vascular Rho-kinase activation is a protective cardiovascular mechanism in obese female mice

This study shows that obese female mice have suppressed vascular Rho-kinase activation, which protects against cardiovascular issues, unlike male mice.

Progranulin maintains blood pressure and vascular tone dependent on EphrinA2 and Sortilin1 receptors and eNOS activation

This study shows that progranulin regulates blood pressure and vascular tone through EphrinA2, Sortilin1 receptors, and eNOS activation, with PGRN deficiency causing hypertension and vascular dysfunction.

Light-entrained and brain-tuned circadian circuits regulate ILC3 and gut homeostasis

This study shows that circadian circuits regulated by light and the brain control ILC3 function, gut homeostasis, and metabolism.