A. W. Lund

Lymphatic vessel transit seeds precursors to cytotoxic resident memory T cells in skin draining lymph nodes

The paper tracks anti-viral CD8+ T cells to show lymphatic transit seeds LN TRM, which provide protection against rechallenge.

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence

This study shows CXCR6 supports dermal CD8+ T cell survival and transition to long-term tissue residence by enhancing metabolic adaptation and reducing apoptosis.

T cell Egress via Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma

The paper shows that T cell egress via lymphatic vessels limits intratumoral T cell diversity, and that CXCR4 inhibition enhances T cell retention and improves immunotherapy response.

Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and its Tumor Microenvironment

This study uses single-cell RNA sequencing to analyze how chemotherapy affects PDAC tumor cells and their microenvironment, finding limited transcriptional shifts and reduced TIGIT-mediated immune checkpoint activity.

Quantitative multiplex immunohistochemistry reveals inter- and intra-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma

This paper uses quantitative multiplex immunohistochemistry to analyze lymphovascular and immune heterogeneity in primary cutaneous melanoma, finding that vessel subtypes correlate with immune infiltration and metastatic risk.

Infection-induced dermal lymphatic zippering restricts viral dissemination from skin and promotes anti-viral CD8+ T cell expansion.

This study shows that vaccinia virus infection causes dermal lymphatic capillary zippering via VEGFR2, which limits viral spread and enhances CD8+ T cell responses.

A neural crest stem cell-like state drives nongenetic resistance to targeted therapy in melanoma

This study identifies a neural crest stem cell-like state in melanoma minimal residual disease that drives nongenetic resistance to MAPK-targeted therapy and shows that targeting FAK/SRC signaling can delay relapse.