Author

B. Magnuson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

C. A. Lyssiotis· 3 shared H. Hong· 2 shared L. Franchi· 2 shared L. Zhang· 2 shared M. Ljungman· 2 shared M. Pasca di Magliano· 2 shared M. Shan· 2 shared N. Mbah· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

C. A. Lyssiotis

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Author profile →

6 papers

Recent·Most cited

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

C. Cheng, J. Hu, R. Mannan, R. Bhattacharyya, N. J. Rossiter, B. Magnuson, J. P. Wisniewski, Y. Zheng, L. Xiao, C. Li, D. Awad, T. He, Y. Bao, Y. Zhang, X. Cao, , A. M. Chinnaiyan

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

bioRxiv · Mar 18, 2024Cancer Biology

Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in Mice

I. Barravecchia, J. M. Lee, J. Manassa, B. Magnuson, S. Cavanaugh, N. G. Steele, C. Espinoza, C. J. Galban, N. Ramnath, T. L. Frankel, M. Pasca di Magliano, S. Galban

This study develops a mouse model to investigate how IPF-related fibrosis influences lung cancer development and identifies immune-suppressive mechanisms and therapeutic targets.

bioRxiv · Jun 20, 2023Cancer Biology

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

A. Melnick, S. Liang, Y. Liu, Q. Wang, N. Dean, E. Choe, N. Kunnath, G. Bodanapu, C. Mullin, F. Akter, K. Lin, B. Magnuson, S. Kumar, D. B. Lombard, A. G. Muntean, , M. Y. Chiang

This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.

bioRxiv · Jan 22, 2023Cancer Biology

Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG

N. Mbah, A. Myers, C. Chung, J. Thompson, H. Hong, P. Sajjakulnukit, Z. Nwosu, M. Shan, S. Sweha, D. Maydan, B. Chen, L. Zhang, B. Magnuson, Z. Zui, D. Wahl, , C. A. Lyssiotis

This study identifies metabolic vulnerabilities in DIPG subtypes and shows that targeting these vulnerabilities with specific drugs can extend survival in preclinical models.

bioRxiv · Mar 1, 2022 · PreprintCancer Biology

OXPHOS Promotes Apoptotic Resistance and Persistence in TH17 cells

H. Hong, N. Mbah, M. Shan, K. Loesel, L. Lin, P. Sajjakulnukit, A. Andren, A. Hayashi, B. Magnuson, Z. Li, Y. Xie, L. Zhang, Y. L. Lei, A. Opipari, R. J. Arguello, , C. A. Lyssiotis

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

bioRxiv · Oct 1, 2021 · PreprintImmunology

HNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem Cells

E. Abel, M. Goto, B. Magnuson, S. Abraham, N. Ramanathan, E. Hotaling, A. A. Alaniz, C. Kumar-Sinha, M. L. Dziubinski, S. Urs, L. Wang, J. Shi, M. Waghray, M. Ljungman, H. C. Crawford, D. M. Simeone

This study identifies HNF1A as a central regulator of pancreatic cancer stem cells and a novel oncogene in pancreatic ductal adenocarcinoma.

bioRxiv · Dec 22, 2017Cancer Biology