Author

D. M. Snead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. E. Leschziner· 2 shared S. L. Reck-Peterson· 2 shared A. K. Shiau· 1 shared A. M. Dickey· 1 shared C. K. Deniston· 1 shared E. Villa· 1 shared I. Lahiri· 1 shared J. Böhning· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

A. E. Leschziner

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2 papers

Recent·Most cited

Structural basis for Parkinson's Disease-linked LRRK2's binding to microtubules

D. M. Snead, M. Matyszewski, A. M. Dickey, Y. X. Lin, A. E. Leschziner, S. L. Reck-Peterson

This study determines the structural basis of LRRK2's microtubule binding, identifies key residues involved, and shows their disruption affects binding without impacting kinase activity.

bioRxiv · Jan 21, 2022Cell Biology

Parkinson's Disease-linked LRRK2 structure and model for microtubule interaction

C. K. Deniston, J. Salogiannis, S. Mathea, D. M. Snead, I. Lahiri, O. Donosa, R. Watanabe, J. Böhning, A. K. Shiau, S. Knapp, E. Villa, S. L. Reck-Peterson, A. E. Leschziner

This study reports the structure of LRRK2 and its interaction with microtubules, showing that its conformation regulates binding and affects motor protein function.

bioRxiv · Jan 6, 2020Biophysics