Author

O. Donosa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. E. Leschziner· 1 shared A. K. Shiau· 1 shared C. K. Deniston· 1 shared C. R. Detrick· 1 shared D. M. Snead· 1 shared D. Petrov· 1 shared E. Villa· 1 shared H. Xu· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. E. Leschziner

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2 papers

Recent·Most cited

Efficient and multiplexed somatic genome editing with Cas12a mice

J. D. Hebert, H. Xu, Y. J. Tang, P. A. Ruiz, C. R. Detrick, J. Wang, N. W. Hughes, O. Donosa, L. Andrejka, S. Karmakar, I. Aboiralor, R. Tang, J. Sage, L. Cong, D. Petrov, M. M. Winslow

This study develops transgenic Cas12a mice to enable efficient, multiplexed somatic genome editing for studying complex genetic interactions in vivo.

bioRxiv · Mar 7, 2024Cancer Biology

Parkinson's Disease-linked LRRK2 structure and model for microtubule interaction

C. K. Deniston, J. Salogiannis, S. Mathea, D. M. Snead, I. Lahiri, O. Donosa, R. Watanabe, J. Böhning, A. K. Shiau, S. Knapp, E. Villa, S. L. Reck-Peterson, A. E. Leschziner

This study reports the structure of LRRK2 and its interaction with microtubules, showing that its conformation regulates binding and affects motor protein function.

bioRxiv · Jan 6, 2020Biophysics