BiochemistrybioRxivPreprint
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
D. Mellott, C.-T. Tseng, A. Drelich…·J. H. McKerrow
This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.
DOI 10.1101/2020.10.23.347534