Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
12 papers
Recent·Most cited
S. L. Leibel, R. N. McVicar, R. Murad, E. M. Kwong, A. E. Clark, A. Alvarado, B. A. Grimmig, R. Nuryyev, R. E. Young, J. C. Lee, W. Peng, Y. P. Zhu, E. Griffis, C. J. Nowell, B. James, , E. Y. Snyder
This study shows that surfactant proteins mediate an intrinsic inflammatory response in the lung to defend against SARS-CoV-2 infection.
bioRxiv · Jan 26, 2023 · PreprintImmunology
G. Almanza, V. Kouznetsova, A. E. Clark, E. Olmedillas, A. Castro, I. F. Tsigelny, Y. Wu, G. F. Gao, E. Ollmann Saphire, A. F. Carlin, M. Zanetti
This study shows that structure-selected RBM immunogens induce polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.
PLOS Pathogens · Jul 21, 2022Peer-reviewedImmunology
R. Li, M. Mor, B. Ma, A. E. Clark, J. Alter, M. Werbner, J. Lee, S. L. Leibel, A. F. Carlin, M. Dassau, M. Gal-Tanamy, B. A. Croker, Y. Xiang, N. T. Freund
This study evaluates the neutralizing activity of nine anti-SARS-CoV-2 monoclonal antibodies against variants of concern and reveals their structural mechanisms of action.
bioRxiv · Apr 3, 2022Immunology
A. E. Clark, C. C. Adamson, K. E. Carothers, B. A. P. Roxas, V. Viswanathan, G. Vedantam
This study shows that SigL, an alternative sigma factor in C. difficile, affects toxin production, sporulation, and cell surface properties differently in two strains.
bioRxiv · Jan 26, 2022Microbiology
R. T. Schooley, A. F. Carlin, J. R. Beadle, N. Valiaeva, X.-Q. Zhang, A. E. Clark, R. E. McMillian, S. L. Leibel, R. N. McVicar, J. Xie, A. F. Garretson, V. I. Smith, J. A. Murphy, K. Y. Hostetler
This paper develops orally bioavailable lipid prodrugs of Remdesivir that show submicromolar anti-SARS-CoV-2 activity and therapeutic plasma levels in Syrian hamsters.
Antimicrobial Agents and Chemotherapy · Sep 17, 2021Peer-reviewedMicrobiology
R. A. Salido, V. J. Cantu, A. E. Clark, S. L. Leibel, A. Foroughishafiei, A. Saha, A. Hakim, A. Nouri, A. L. Lastrella, A. Castro-Martinez, A. Plascencia, B. Kapadia, B. Xia, C. Ruiz, C. Marotz, , R. Knight
This study compares RT-qPCR signal intensity and persistence of heat-inactivated and infectious SARS-CoV-2 on different surfaces, showing similar decay patterns and enabling simplified environmental monitoring protocols.
bioRxiv · Jul 16, 2021 · PreprintMicrobiology
A. Sen, B. C. Prager, D. Park, Z. Zhu, R. C. Gimple, J. A. Bernatchez, S. Beck, A. E. Clark, J. L. Siqueira-Neto, J. N. Rich, G. P. McVicker
This study identifies genes with allele-specific expression in glioblastoma stem cells, finding SLFN11 loss linked to drug resistance and susceptibility to Zika virus.
bioRxiv · Jun 22, 2021Cancer Biology
D. R. Sandoval, T. Mandel Clausen, C. Nora, J. A. Magida, A. P. Cribbs, A. Denardo, A. E. Clark, A. F. Garretson, J. K. C. Coker, A. Narayanan, S. A. Majowicz, M. Philpott, C. Johansson, J. E. Dunford, C. B. Spliid, , Mazitsch
This study identifies halofuginone as a potent inhibitor of SARS-CoV-2 infection and replication by reducing heparan sulfate biosynthesis and suppressing viral replication.
bioRxiv · Mar 22, 2021 · PreprintMicrobiology
J. G. Gleeson, L. Wang, D. Sievert, A. E. Clark, H. Federman, B. D. Gastfriend, E. Shusta, S. Palecek, A. Carlin, A. E. Clark
This study demonstrates that pericyte-like cells in cortical organoids can support SARS-CoV-2 infection and replication, serving as a new model for neural infection.
bioRxiv · Feb 9, 2021Microbiology
D. Mellott, C.-T. Tseng, A. Drelich, P. Fajtova, B. C. Chenna, D. Kostomiris, J. C. Hsu, J. Zhu, Z. Taylor, V. Tat, A. Katzfuss, L. Li, M. A. Giardini, D. Skinner, K. Hirata, , J. H. McKerrow
This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.
bioRxiv · Oct 23, 2020 · PreprintBiochemistry
J. A. Bernatchez, M. Coste, S. Beck, G. A. Wells, L. A. Luna, A. E. Clark, Z. Zhu, C. D. Sohl, B. W. Purse, J. L. Siqueira-Neto
This study evaluates the antiviral activity of nucleoside ProTides against Zika virus in human neural stem cells, identifying effective compounds and elucidating their mechanism of action.
bioRxiv · Jan 29, 2019Microbiology
J. A. Bernatchez, Z. Yang, M. Coste, J. Li, S. Beck, Y. Liu, A. E. Clark, Z. Zhu, L. A. Luna, C. Sohl, B. W. Purse, R. Li, J. L. Siqueira-Neto
The paper develops and validates a high-content imaging assay to assess antiviral activity of small-molecule inhibitors against Zika virus by detecting cytopathic effects.
bioRxiv · Apr 17, 2018Microbiology