J. H. McKerrow

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

An Orally Available Cathepsin L Inhibitor Protects Lungs Against SARS-CoV-2-Induced Diffuse Alveolar Damage in African Green Monkeys

This study shows that the orally available cathepsin L inhibitor K777 reduces SARS-CoV-2-induced lung damage in African green monkeys.

Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents Against Trypanosoma cruzi

This study identifies leucinostatins from fungi as potent antiparasitic agents against Trypanosoma cruzi, with one showing in vivo efficacy in a mouse model.

Insights into the L3 to L4 developmental program through proteomics

This study identifies proteomic changes during the L3 to L4 molt of B. malayi, highlighting key pathways and proteins involved in development and immune evasion.

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.

Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas disease

The paper uses spatial metabolomics to identify localized metabolic changes in heart tissue of mice chronically infected with Trypanosoma cruzi, revealing distinct metabolic perturbations from parasite burden sites.

High-throughput screening of the ReFRAME library identifies potential drug repurposing candidates for Trypanosoma cruzi

The paper screens 12,000 compounds from the ReFRAME library against Trypanosoma cruzi, identifying 7 with potent in vitro activity and therapeutic index ≥10.