Cannabinoid Combination Targets NOTCH1-Mutated T-ALL Through the Integrated Stress Response Pathway
E. Besser, A. Gelfand, S. Procaccia, P. Berman, D. Meiri
This study identifies three cannabinoids that target NOTCH1-mutated T-ALL by activating the integrated stress response pathway, reducing Notch1 activity, and inducing apoptosis.
bioRxiv · Aug 20, 2023Cancer Biology