Author

D. Melgari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:electrophysiology· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

A. Coulombe· 2 shared E. Balse· 2 shared G. Dilanian· 2 shared N. Doisne· 2 shared A. Beuriot· 1 shared C. A. Eichel· 1 shared C. Barbier· 1 shared C. L. Lei· 1 shared

Activity by Year

2019-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

A. Coulombe

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Author profile →

3 papers

Recent·Most cited

Distinct CASK domains control cardiac sodium channel membrane expression and focal adhesion anchoring

A. Beuriot, C. A. Eichel, G. Dilanian, F. Louault, D. Melgari, N. Doisne, A. Coulombe, S. N. Hatem, E. Balse

The paper identifies three critical domains of CASK in cardiomyocytes: HOOK for dystrophin-glycoprotein complex binding and L27B/GUK for inhibiting NaV1.5 channel membrane expression.

bioRxiv · Oct 21, 2019Physiology

Microtubule polymerization state and clathrin-dependent internalization regulate dynamics of cardiac potassium channel

D. Melgari, C. Barbier, G. Dilanian, C. Rucker-Martin, N. Doisne, A. Coulombe, s. hatem, E. Balse

This study investigates how microtubule polymerization and clathrin-dependent internalization regulate the dynamics of the cardiac potassium channel KV1.5 in atrial myocytes and human atrial fibrillation biopsies.

bioRxiv · Oct 16, 2019Cell Biology

Rapid characterisation of hERG channel kinetics II: temperature dependence

C. L. Lei, M. Clerx, K. A. Beattie, D. Melgari, J. Hancox, D. J. Gavaghan, L. Polonchuk, K. Wang, G. R. Mirams

This paper characterizes the temperature dependence of hERG channel kinetics using a high-throughput protocol and finds that Q10 coefficients poorly represent the temperature sensitivity, while a generalized Eyring relationship fits better.

bioRxiv · Apr 16, 2019Biophysics