Author

C. L. Lei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

G. R. Mirams· 6 shared M. Clerx· 5 shared D. G. Whittaker· 3 shared D. J. Gavaghan· 3 shared K. Wang· 2 shared L. Polonchuk· 2 shared A. P. Clark· 1 shared D. J. Christini· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersBiophysics

G. R. Mirams

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Author profile →

6 papers

Recent·Most cited

Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics

G. R. Mirams, M. Clerx, D. G. Whittaker, C. L. Lei

This paper introduces an optimal experimental design for ion channel gating characterization by efficiently exploring the phase-voltage space using hERG/Kv11.1 currents.

bioRxiv · May 2, 2024Biophysics

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug-induced proarrhythmic risk

C. L. Lei, D. G. Whittaker, G. R. Mirams

This study evaluates how uncertainty in hERG binding mechanisms affects in silico predictions of drug-induced proarrhythmic risk.

bioRxiv · Mar 14, 2023 · PreprintBiophysics

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

A. P. Clark, M. Clerx, S. Wei, C. L. Lei, T. de Boer, G. R. Mirams, D. J. Christini, T. Krogh-Madsen

This paper shows seal-leak current affects iPSC-CM action potential morphology even with high seal resistance, and suggests ways to improve data interpretation and modeling.

bioRxiv · Oct 13, 2022Physiology

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

C. L. Lei, M. Clerx, D. G. Whittaker, D. J. Gavaghan, T. P. de Boer, G. R. Mirams

This paper develops a mathematical model to explain variability in patch-clamp data by accounting for experimental artefacts rather than cell-specific ion channel kinetics.

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · May 25, 2020Peer-reviewedBiophysics

Rapid characterisation of hERG channel kinetics II: temperature dependence

C. L. Lei, M. Clerx, K. A. Beattie, D. Melgari, J. Hancox, D. J. Gavaghan, L. Polonchuk, K. Wang, G. R. Mirams

This paper characterizes the temperature dependence of hERG channel kinetics using a high-throughput protocol and finds that Q10 coefficients poorly represent the temperature sensitivity, while a generalized Eyring relationship fits better.

bioRxiv · Apr 16, 2019Biophysics

Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system

C. L. Lei, M. Clerx, D. J. Gavaghan, L. Polonchuk, G. R. Mirams, K. Wang

This paper introduces a 15-second high-throughput protocol to rapidly characterize hERG channel kinetics using automated patch clamp systems and validates it with a hierarchical Bayesian model.

bioRxiv · Apr 16, 2019Biophysics