Author

M. Clerx

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 8 Research Focus:benchmarking· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

G. R. Mirams· 8 shared C. L. Lei· 5 shared D. J. Gavaghan· 5 shared K. Wang· 3 shared L. Polonchuk· 3 shared D. G. Whittaker· 2 shared K. A. Beattie· 2 shared A. Agrawal· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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8 shared papersBiophysics

G. R. Mirams

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Author profile →

8 papers

Recent·Most cited

Variability in reported midpoints of (in)activationof cardiac INa

M. Clerx, P. G. A. Volders, G. R. Mirams

This paper reviews and visualizes variability in reported midpoints of activation and inactivation of cardiac INa, finding large between-experiment variation and classifying contributing factors.

bioRxiv · May 8, 2024Cell Biology

Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics

G. R. Mirams, M. Clerx, D. G. Whittaker, C. L. Lei

This paper introduces an optimal experimental design for ion channel gating characterization by efficiently exploring the phase-voltage space using hERG/Kv11.1 currents.

bioRxiv · May 2, 2024Biophysics

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

A. P. Clark, M. Clerx, S. Wei, C. L. Lei, T. de Boer, G. R. Mirams, D. J. Christini, T. Krogh-Madsen

This paper shows seal-leak current affects iPSC-CM action potential morphology even with high seal resistance, and suggests ways to improve data interpretation and modeling.

bioRxiv · Oct 13, 2022Physiology

Models of the cardiac L-type calcium current: a quantitative review

A. Agrawal, K. Wang, L. Polonchuk, J. Cooper, M. Hendrix, D. J. Gavaghan, G. R. Mirams, M. Clerx

This paper reviews 73 mammalian models of the cardiac L-type calcium current, finds large variability in their predictions, and provides model code and data sources.

bioRxiv · Oct 4, 2021Cell Biology

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

C. L. Lei, M. Clerx, D. G. Whittaker, D. J. Gavaghan, T. P. de Boer, G. R. Mirams

This paper develops a mathematical model to explain variability in patch-clamp data by accounting for experimental artefacts rather than cell-specific ion channel kinetics.

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · May 25, 2020Peer-reviewedBiophysics

Four ways to fit an ion channel model

M. Clerx, K. A. Beattie, D. J. Gavaghan, G. R. Mirams

The paper compares four methods for fitting ion channel models to single-cell measurements, finding that Methods 3 and 4 provide the best predictions.

bioRxiv · Apr 16, 2019Biophysics

Rapid characterisation of hERG channel kinetics II: temperature dependence

C. L. Lei, M. Clerx, K. A. Beattie, D. Melgari, J. Hancox, D. J. Gavaghan, L. Polonchuk, K. Wang, G. R. Mirams

This paper characterizes the temperature dependence of hERG channel kinetics using a high-throughput protocol and finds that Q10 coefficients poorly represent the temperature sensitivity, while a generalized Eyring relationship fits better.

bioRxiv · Apr 16, 2019Biophysics

Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system

C. L. Lei, M. Clerx, D. J. Gavaghan, L. Polonchuk, G. R. Mirams, K. Wang

This paper introduces a 15-second high-throughput protocol to rapidly characterize hERG channel kinetics using automated patch clamp systems and validates it with a hierarchical Bayesian model.

bioRxiv · Apr 16, 2019Biophysics