Phosphorylation of HspB1 regulates its mechanosensitive molecular chaperone interaction with native filamin C
M. Collier, T. R. Alderson, C. de Villiers, D. Nicholls, H. Gastall, T. Allison, M. Degiacomi, D. Fuerst, P. van de Ven, K. Djinovic-Carugo, A. Baldwin, H. Watkins, K. Gehmlich, J. L. Benesch
This study shows phosphorylation of HspB1 enhances its interaction with filamin C under mechanical stress, stabilizing its structure and protecting it from over-extension.
bioRxiv · May 18, 2018Biophysics