K. Djinovic-Carugo

Unlocking Predictive Power: A Machine Learning Tool Derived from In-Depth Analysis to Forecast the Impact of Missense Variants in Human Filamin C

The paper develops a machine learning model to predict the impact of missense variants in human filamin C, achieving high accuracy in distinguishing pathogenic from non-pathogenic variants.

Characterisation of TbSmee1 indicates that endocytosis is required for access of surface-bound cargo to the trypanosome flagellar pocket

This study characterizes TbSmee1 in Trypanosoma brucei, showing that endocytosis is required for surface-bound cargo to access the flagellar pocket.

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators

Molecular basis of F-actin regulation and sarcomere assembly via myotilin

This study reveals the structural dynamics of myotilin and its interaction with F-actin, showing how it stabilizes Z-discs and displaces tropomyosin.

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats

This study investigates MORN repeat proteins, revealing they are protein-protein interaction modules rather than lipid-binding modules, based on structural and functional analyses of TbMORN1 and homologs.

PHF3 regulates neuronal gene expression through the new Pol II CTD reader domain SPOC

This study identifies PHF3 as a CTD-binding factor that regulates neuronal gene expression by inhibiting Pol II elongation and mRNA stability.

Phosphorylation of HspB1 regulates its mechanosensitive molecular chaperone interaction with native filamin C

This study shows phosphorylation of HspB1 enhances its interaction with filamin C under mechanical stress, stabilizing its structure and protecting it from over-extension.