T. R. Alderson

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

This study shows PARP1 condensates partition DNA repair proteins and enhance DNA ligation through PARylation-dependent mechanisms.

Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2

This paper shows AlphaFold2 can predict structures of conditionally folded intrinsically disordered regions with high precision, revealing their prevalence in human and prokaryotic proteins and their association with disease mutations.

Dysregulated interactions triggered by a neuropathy-causing mutation in the IPV motif of HSP27

This study investigates how the P182L mutation in HSP27's IxI/V motif disrupts protein interactions, leading to aggregation and disease.

Automatic structure-based NMR methyl resonance assignment in large proteins

MethylFLYA automatically assigns methyl groups in large proteins using NOESY data, achieving high accuracy and efficiency compared to manual methods.

Local unfolding of the HSP27 monomer regulates chaperone activity

This study shows that redox-induced monomerization of HSP27 enhances its chaperone activity but also increases aggregation risk, with mutations in an unstructured region linked to neuropathies.

Phosphorylation of HspB1 regulates its mechanosensitive molecular chaperone interaction with native filamin C

This study shows phosphorylation of HspB1 enhances its interaction with filamin C under mechanical stress, stabilizing its structure and protecting it from over-extension.