A faithful in vivo model of human macrophages in metastatic melanoma
V. Voillet, T. R. Berger, K. M. McKenna, K. G. Paulson, K. S. Smythe, D. S. Hunter, W. J. Valente, S. J. Weaver, J. S. Campbell, T. S. Kim, D. R. Byrd, J. H. Bielas, R. H. Pierce, A. G. Chapuis, R. Gottardo, A. Rongvaux
The paper develops a humanized mouse model of metastatic melanoma that supports tumor spread and recapitulates patient macrophage transcriptomes, linking them to poor survival.
bioRxiv · Sep 9, 2021 · PreprintImmunology