Author

D. R. Owen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Casimiro-Garcia· 1 shared A. Chaikuad· 1 shared A. Dong· 1 shared A. K. Yazdi· 1 shared A. T. Londregan· 1 shared C. Arrowsmith· 1 shared C. Subramanyam· 1 shared D. Barsyte-Lovejoy· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

A. Casimiro-Garcia

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Author profile →

2 papers

Recent·Most cited

Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex

A. K. Yazdi, S. Perveen, X. Song, A. Dong, M. Szewczyk, M. Calabrese, A. Casimiro-Garcia, C. Subramanyam, M. S. Dowling, E. Ficici, J. Lee, J. I. Montgomery, T. N. O'Connell, G. J. Skrzypek, T. P. Tran, , D. R. Owen

The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.

bioRxiv · Nov 13, 2023Biophysics

Structure and inhibitor binding characterization of oncogenic MLLT1 mutants

X. Ni, A. T. Londregan, D. R. Owen, S. Knapp, A. Chaikuad

The paper reports crystal structures of oncogenic MLLT1 mutants, showing conformational changes and altered histone binding, but demonstrates that these mutants can still be targeted by acetyllysine mimetic inhibitors.

bioRxiv · Feb 8, 2021Biochemistry