S. Perveen

Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity

The paper identifies potent covalent inhibitors of Chikungunya nsP2 protease and establishes structure-activity relationships to guide inhibitor design.

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

A resource to enable chemical biology and drug discovery of WDR Proteins

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex

The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor

The paper investigates how a small-molecule inhibitor binds to and inactivates Cbl-b, revealing a structural mechanism that locks the protein in an inactive conformation.

Design And Optimization Studies Of Tablet In Tablet Formulation Of Diclofenac And Misoprostol: Application Of Response Surface Methodolgy And Compressional Behaviour Strategy

This study develops compression-coated tablets of diclofenac and misoprostol using response surface methodology and evaluates their quality and stability.

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

This study identifies small molecule antagonists of RBBP4's top pocket, competes with protein and histone interactions, and reports the first crystal structure of RBBP4 with a small molecule.

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex

The paper develops a radioactivity-based high-throughput screening assay for the SARS-CoV-2 nsp10-nsp16 complex and optimizes it for HTS with a Z'-factor of 0.83.

A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19

The paper develops a fluorescence polarization assay for screening RNA-competitive inhibitors of the SARS-CoV-2 nsp10-nsp16 complex, validated with 1124 compounds.

Intense expression of Neurokinin-1 Receptor is associated with Urothelial carcinoma

This study examines NK-1R expression in urothelial carcinoma and finds it is intensely expressed in high-grade cases, suggesting a potential diagnostic and therapeutic marker.

Performance evaluation of biosurfactant stabilized microbubbles in enhanced oil recovery

This study evaluates biosurfactant-stabilized microbubbles for tertiary oil recovery, finding they achieve higher oil recovery (46%) than aqueous biosurfactant solutions (36%) with lower pressure requirements.