NK cells negatively regulate CD8 T cells to promote immune exhaustion and chronic Toxoplasma gondii infection
J. P. Gigley, D. L. Ivanova, R. Krempels, S. L. Denton, K. D. Fettel, G. M. Saltz, D. Rach, R. Fatima, T. Mundhenke, J. Materi, I. R. Dunay
This study shows that NK cells in chronic Toxoplasma gondii infection promote CD8+ T cell exhaustion and parasite persistence by developing a modified NK cell population that suppresses CD8+ T cell function.
bioRxiv · Dec 5, 2019Immunology