Author

S. L. Denton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:flow cytometry· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

J. P. Gigley· 3 shared D. L. Ivanova· 2 shared A. Mejia· 1 shared B. A. Fox· 1 shared D. J. Bzik· 1 shared D. Rach· 1 shared G. M. Saltz· 1 shared H. K. Keplinger· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

J. P. Gigley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Transferrin Receptor 1 is Required for CD4+ T Cell Iron-Dependent Response During Acute Toxoplasma gondii Infection

S. L. Denton, T. Roy, H. K. Keplinger, S. K. Ng, J. P. Gigley

This study shows that iron acquisition by CD4+ T cells is essential for their activation and long-term protection against Toxoplasma gondii infection.

bioRxiv · Jun 28, 2023 · PreprintImmunology

Theft of Host Transferrin Receptor-1 by Toxoplasma gondii is required for infection

S. L. Denton, A. Mejia, L. L. Nevarez, M. P. Soares, B. A. Fox, D. J. Bzik, J. P. Gigley

This study shows Toxoplasma gondii steals host transferrin receptor 1 and transferrin to enhance growth, but not iron levels.

bioRxiv · Jun 23, 2023 · PreprintMicrobiology

NK cells negatively regulate CD8 T cells to promote immune exhaustion and chronic Toxoplasma gondii infection

J. P. Gigley, D. L. Ivanova, R. Krempels, S. L. Denton, K. D. Fettel, G. M. Saltz, D. Rach, R. Fatima, T. Mundhenke, J. Materi, I. R. Dunay

This study shows that NK cells in chronic Toxoplasma gondii infection promote CD8+ T cell exhaustion and parasite persistence by developing a modified NK cell population that suppresses CD8+ T cell function.

bioRxiv · Dec 5, 2019Immunology

Anti-Asialo GM1 treatment during secondary Toxoplasma gondii infection is lethal and depletes T cells

D. L. Ivanova, S. L. Denton, J. Gigley

This study shows that anti-ASGM1 treatment during secondary Toxoplasma gondii infection causes 100% mortality and depletes T cells, particularly CD8+ effector T cells, highlighting ASGM1 as a marker of activated T cells.

bioRxiv · Feb 18, 2019 · PreprintImmunology