Author

J. P. Gigley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1

Frequent Co-Authors

S. L. Denton· 3 shared A. Mejia· 1 shared B. A. Fox· 1 shared C. Cordonnier· 1 shared C. M. West· 1 shared D. J. Bzik· 1 shared D. L. Ivanova· 1 shared D. L. Levy· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersImmunology

S. L. Denton

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transferrin Receptor 1 is Required for CD4+ T Cell Iron-Dependent Response During Acute Toxoplasma gondii Infection

S. L. Denton, T. Roy, H. K. Keplinger, S. K. Ng, J. P. Gigley

This study shows that iron acquisition by CD4+ T cells is essential for their activation and long-term protection against Toxoplasma gondii infection.

bioRxiv · Jun 28, 2023 · PreprintImmunology

Theft of Host Transferrin Receptor-1 by Toxoplasma gondii is required for infection

S. L. Denton, A. Mejia, L. L. Nevarez, M. P. Soares, B. A. Fox, D. J. Bzik, J. P. Gigley

This study shows Toxoplasma gondii steals host transferrin receptor 1 and transferrin to enhance growth, but not iron levels.

bioRxiv · Jun 23, 2023 · PreprintMicrobiology

The Toxoplasma Oxygen Sensing Protein, TgPhyA, Is Required for Resistance to Interferon-gamma Mediated Nutritional Immunity

C. Cordonnier, M. Mandalasi, J. P. Gigley, E. Wohlfert, C. M. West, I. Blader

This study shows that TgPHYa, an oxygen-sensing protein in Toxoplasma, is essential for parasite virulence and survival in immune cells by enabling tryptophan scavenging during IFN-gamma-induced nutritional immunity.

bioRxiv · May 16, 2023 · PreprintMicrobiology

Nuclear Transport Factor 2 (NTF2) suppresses metastatic melanoma by modifying cell migration, metastasis, and gene expression

L. D. Vukovic, K. H. White, J. P. Gigley, D. L. Levy

This study shows that increasing NTF2 expression in metastatic melanoma cells reduces proliferation, motility, and metastasis while increasing apoptosis and survival.

bioRxiv · Mar 13, 2020Cancer Biology

NK cells negatively regulate CD8 T cells to promote immune exhaustion and chronic Toxoplasma gondii infection

J. P. Gigley, D. L. Ivanova, R. Krempels, S. L. Denton, K. D. Fettel, G. M. Saltz, D. Rach, R. Fatima, T. Mundhenke, J. Materi, I. R. Dunay

This study shows that NK cells in chronic Toxoplasma gondii infection promote CD8+ T cell exhaustion and parasite persistence by developing a modified NK cell population that suppresses CD8+ T cell function.

bioRxiv · Dec 5, 2019Immunology