S. J. Lee

PathCLAST: Pathway-Augmented Contrastive Learning with Attention for Spatial Transcriptomics

PathCLAST improves spatial domain identification in spatial transcriptomics by integrating gene expression, histopathology, and pathway information, achieving better clustering accuracy than existing methods.

In situ cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels

This paper develops core/shell microgels for in situ cartilage tissue engineering, enabling immediate implantation and spontaneous fusion of cell condensates without prior in vitro culture.

Levodopa reduces consumption of multiple classes of addictive substances in rats

This study shows that L-DOPA reduces alcohol and opioid self-administration in rats, suggesting a role for dopamine signaling in drug consumption across multiple substance classes.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

Pharmacologic Inhibition of DYRK1A Results in MYC Hyperactivation and ERK Hyperphosphorylation rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

This study shows that inhibiting DYRK1A in KMT2A-R ALL cells leads to MYC upregulation and ERK hyperphosphorylation, making them sensitive to BCL2 inhibition.

Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential

The paper identifies Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells through increased motility, elasticity, and survival in circulation.

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

This study shows indoxyl sulfate induces trained immunity in monocytes via AhR-dependent arachidonic acid pathway, contributing to inflammation in ESRD.

Temporal coordination between chromosome mobility and homologous recombination

This study shows that chromosome mobility and homologous recombination events are temporally coordinated, with delays in early processing affecting downstream repair steps.

4D Cell-Condensate Bioprinting

This paper introduces a 4D bioprinting method to create shape-morphing cell condensate bilayers with predefined geometries, demonstrating its use in forming complex shapes like 'C' and helix-shaped cartilage-like tissues from hMSCs.

Effects of Platycodon grandiflorum on Gut Microbiota and Immune System of Immunosuppressed Mouse

This study investigates the effects of Platycodon grandiflorum diets on gut microbiota and immune system in immunosuppressed mice, finding increased microbial abundance and immune-related biomarker changes.

Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries

This study develops a stem cell-laden hydrogel bioink that enables high-resolution and fidelity 3D bioprinting of complex tissue structures.

Viscous medium-based crystal support in sample holder for fixed-target serial femtosecond crystallography

This paper introduces a viscous medium-based sample holder for fixed-target serial femtosecond crystallography, enabling stable crystal support for various sizes and shapes.

Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging

This paper demonstrates the feasibility of using PET imaging to track 89Zr-DFO-labeled CAR T-cells in vivo, showing their distribution and migration over time.

Living cell-only bioink and photocurable supporting medium for printing and generation of engineered tissues with complex geometries

This paper introduces a cell-only bioink and supporting medium for 3D printing and long-term culture of functional tissues without a biomaterial scaffold.

MMOD-induced structural changes of hydroxylase in soluble methane monooxygenase

The paper reports the crystal structure of the MMOH-MMOD complex, revealing how MMOD inhibits MMOH catalytic activity by competing with MMOB and altering the di-iron centre geometry.