Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets
J. M. Lee, J. Zeng, P. Liu, M. A. Nguyen, D. S. Loustaunau, D. Bauer, N. K. Yilmaz, S. Wolfe, C. A. Schiffer
This study develops stabilized Cas-embedded base editors (sCE_CBEs) that enable efficient and accurate C-to-T editing with minimal off-target effects in hematopoietic stem and progenitor cells.
bioRxiv · Feb 8, 2024 · PreprintBiochemistry