J. M. Lee

A Third COVID-19 Vaccine Dose in Kidney Transplant Recipients Induces Antibody Response to Vaccine and Omicron Variants but Shows Limited Ig Subclass Switching

This study evaluates antibody responses to a third dose of COVID-19 vaccine in kidney transplant recipients, finding reduced neutralizing antibodies and altered IgG subclass switching compared to healthy controls.

Parallel comparison reveals conservation and re-wiring of abiotic stress response networks across three plant species

The paper compares abiotic stress response networks across three plant species, finding conserved gene sets and functional divergence in transcription factors.

Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets

This study develops stabilized Cas-embedded base editors (sCE_CBEs) that enable efficient and accurate C-to-T editing with minimal off-target effects in hematopoietic stem and progenitor cells.

Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin

The paper maps how HA mutations affect neutralization by serum from different age groups, showing age-dependent antigenic effects and implications for viral evolution.

Addressing the dNTP bottleneck restricting prime editing activity

This study identifies mutations to improve prime editing efficiency in low-dNTP environments by enhancing MMLV-reverse transcriptase and reducing SAMHD1 activity.

Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in Mice

This study develops a mouse model to investigate how IPF-related fibrosis influences lung cancer development and identifies immune-suppressive mechanisms and therapeutic targets.

Injectable ventral spinal stimulator evokes programmable and biomimetic hindlimb motion

This paper describes an injectable spinal stimulator that enables precise and programmable hindlimb movement in mice by targeting ventral spinal regions.

Stitching flexible electronics into the brain

This paper introduces a flexible probe that can be stitched into multiple brain regions of mice to monitor chronic neuronal activity with high stability and minimal immune response.

An Exploratory Multi-Session Study of Learning High-Dimensional Body-Machine Interfacing for Assistive Robot Control

This study explores whether humans can learn to control a high-dimensional assistive robotic arm via body-machine interfacing across multiple sessions.

Learning to Control Complex Rehabilitation Robot Using High-Dimensional Interfaces

This paper demonstrates that a body-machine interface can control a high-dimensional assistive robotic arm for complex tasks, showing learning and skill acquisition in an uninjured population.

Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25 by silkworm, Bombyx mori, and its biochemical analysis.

This study expresses and purifies recombinant Pvs25 from silkworms, demonstrating its potential as a malaria transmission-blocking vaccine candidate with high immunogenicity.

SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis

This study identifies MAPL's role in regulating bile acid synthesis and metabolic homeostasis, showing its loss leads to insulin sensitivity and hepatocellular carcinoma.

Clomipramine suppresses ACE2-mediated SARS-CoV-2 entry

This study shows clomipramine inhibits SARS-CoV-2 entry into cardiomyocytes and synergizes with remdesivir to suppress infection.

Influenza H3 and H1 hemagglutinins have different genetic barriers for resistance to broadly neutralizing stem antibodies

The paper evaluates genetic barriers to resistance against broadly neutralizing antibodies targeting the stem region of influenza H3 and H1 hemagglutinins, finding H3 has lower resistance barriers.

Mitochondria tether to Focal Adhesions during cell migration and regulate their size.

The paper shows mitochondria tether to focal adhesions during cell migration and regulate their size by controlling ATP production.

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

The paper maps how amino-acid mutations in influenza's hemagglutinin affect neutralization by polyclonal human sera, showing individual variation in escape mutations not observed in ferrets.

Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

The paper experimentally measures the effects of all single amino-acid mutations in H3N2 influenza HA on viral growth and shows their correlation with evolutionary success in natural lineages.

Quantifying the effects of single mutations on viral escape from broad and narrow antibodies to an H1 influenza hemagglutinin

The paper identifies and quantifies single amino-acid mutations that confer resistance to broad and narrow antibodies targeting H1 influenza hemagglutinin.

Multiple reference genome sequences of hot pepper reveal the massive evolution of plant disease resistance genes by retroduplication

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.