Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in C. elegans via degradation of Intrinsically Disordered Proteins.
D. Salcedo-Tacuma, N. Asad, G. Howells, R. Anderson, D. M. Smith
This study shows that a hyperactive 20S proteasome in C. elegans improves degradation of misfolded proteins, reduces oxidative damage, and extends lifespan without relying on known proteostasis pathways.
bioRxiv · Apr 4, 2024 · PreprintCell Biology