D. Siemieniak

Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

This study shows that reducing SURF4 in the liver decreases PCSK9 and increases LDLR, leading to lower plasma cholesterol despite reduced lipoprotein secretion.

The ER cargo receptor SURF4 facilitates efficient erythropoietin secretion

This study identifies SURF4 as an ER cargo receptor that facilitates EPO secretion and suggests its modulation could treat erythropoiesis disorders.