Author

B. T. Emmer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Microbiology· 2 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:genetic perturbation / CRISPR· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Ginsburg· 4 shared V. T. Tang· 3 shared C. E. Wobus· 2 shared C. Mirabelli· 2 shared E. J. Sherman· 2 shared E. Kotnik· 2 shared P. J. Lascuna· 2 shared R. Khoriaty· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

D. Ginsburg

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Identification of LMAN1 and SURF4 dependent secretory cargoes

V. T. Tang, P. S. Abbineni, F. da Veiga Leprevost, V. Basrur, B. T. Emmer, A. Nesvizhskii, D. Ginsburg

The paper identifies secretory cargoes dependent on LMAN1 and SURF4 using CRISPR knockout and mass spectrometry in HuH7 cells, revealing distinct cargo repertoires and complex recognition mechanisms.

bioRxiv · Apr 6, 2023Cell Biology

Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection

J. B. Cunha, K. Leix, E. J. Sherman, C. Mirabelli, A. A. Kennedy, A. S. Lauring, A. W. Tai, C. E. Wobus, B. T. Emmer

This study identifies type I interferon signaling as inducing a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection, which may impair alveolar regeneration.

bioRxiv · Feb 28, 2023 · PreprintMicrobiology

Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

V. T. Tang, J. McCormick, B. Xu, Y. Wang, H. Fang, X. Wang, D. Siemieniak, R. Khoriaty, B. T. Emmer, X.-W. Chen, D. Ginsburg

This study shows that reducing SURF4 in the liver decreases PCSK9 and increases LDLR, leading to lower plasma cholesterol despite reduced lipoprotein secretion.

bioRxiv · Aug 1, 2022Physiology

ARF6 is a host factor for SARS-CoV-2 infection in vitro

C. Mirabelli, E. J. Sherman, J. Bragazzi Cunha, J. W. Wotring, J. El Saghir, J. Harder, J. Z. Sexton, B. T. Emmer, C. E. Wobus

This study identifies ARF6 as a host factor critical for SARS-CoV-2 entry and infection in vitro, showing its importance across different cell models.

bioRxiv · Jun 9, 2022 · PreprintMicrobiology

Murine Surf4 is essential for early embryonic development

B. T. Emmer, P. J. Lascuna, E. Kotnik, T. Saunders, R. Khoriaty, D. Ginsburg

This study shows that Surf4 is essential for early embryonic development in mice, as Surf4-/- embryos die between E3.5 and E9.5, while Surf4+/- mice are normal.

bioRxiv · Feb 7, 2019Cell Biology

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

B. T. Emmer, G. G. Hesketh, E. Kotnik, V. T. Tang, P. J. Lascuna, J. Xiang, A.-C. Gingras, X.-W. Chen, D. Ginsburg

This study identifies SURF4 as a cargo receptor that facilitates PCSK9 secretion by linking it to COPII components and confirming its functional role through multiple experimental approaches.

bioRxiv · May 31, 2018Cell Biology