Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification
V. Delgado-Benito, M. Berruezo-Llacuna, R. Altwasser, W. Winkler, S. Balasubramanian, D. Sundaravinayagam, R. Graf, A. Rahjouei, M. Driesner, L. Keller, M. Janz, A. Akalin, M. Di Virgilio
This study identifies Pdap1 as a regulator of mature B cell survival and antibody gene diversification by modulating the integrated stress response and AID expression.
bioRxiv · Jan 30, 2020Immunology