A. Akalin

Oncogene inactivation-induced senescence facilitates tumor relapse

This study shows that oncogene inactivation-induced senescence both limits tumor growth and promotes relapse by creating a pro-recurrence microenvironment.

Dysregulated Pulmonary Inflammatory Responses Exacerbate the Outcome of Secondary Aspergillosis Following Influenza

This study shows that superinfected mice with influenza and Aspergillus fumigatus have higher mortality during early influenza stages due to dysregulated inflammation, not increased fungal growth.

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators

Identifying tumor cells at the single cell level

This paper introduces Ikarus, a machine learning pipeline that identifies tumor cells in single-cell data with high sensitivity and specificity across multiple datasets.

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression

This study shows herpesviruses induce DUX4 expression, which drives viral gene expression by mimicking embryonic genome activation.

PHF3 regulates neuronal gene expression through the new Pol II CTD reader domain SPOC

This study identifies PHF3 as a CTD-binding factor that regulates neuronal gene expression by inhibiting Pol II elongation and mRNA stability.

Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification

This study identifies Pdap1 as a regulator of mature B cell survival and antibody gene diversification by modulating the integrated stress response and AID expression.

A novel IKK- and proteasome-independent mechanism of RelA activation triggers senescence associated secretome via transcriptional repression of NFKBIA

The paper identifies a novel IKK- and proteasome-independent mechanism of RelA activation in senescent cells that drives the senescence-associated secretome through transcriptional repression of NFKBIA.

The conserved histone chaperone LIN-53 links lifespan and healthspan regulation in C. elegans

This study shows LIN-53 links lifespan and healthspan in C. elegans by regulating chromatin and trehalose levels, with implications for evolutionary conservation.

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

This study identifies subtype and relapse-specific long non-coding RNAs in B cell precursor acute lymphoblastic leukemia and links them to molecular pathways and epigenetic regulation.

Mutations In Disordered Regions Cause Disease By Creating Endocytosis Motifs

The paper identifies mutations in disordered regions that create dileucine motifs, leading to clathrin-dependent trafficking and disease.