S. Balasubramanian

hnRNPA1 RGG-box acts a "catalyst" in UP1-induced destabilization of RNA and DNA telomeric G-Quadruplexes

This study investigates how the RGG-box of hnRNPA1 interacts with telomeric G-quadruplexes, showing it preferentially binds to specific structures and can destabilize them, aiding hnRNPA1-UP1 in telomere maintenance.

Bloodmeal metabarcoding of the argasid tick (Ornithodoros turicata Duges) reveals extensive vector-host associations

The paper uses bloodmeal metabarcoding to identify host species fed upon by Ornithodoros turicata ticks, revealing a wide host range and mixed feeding patterns.

Interplay of the folded domain and disordered low-complexity domains along with RNA sequence mediate efficient binding of FUS with RNA

This study uses molecular simulations to investigate how FUS's folded and disordered domains interact with RNA, revealing cooperative binding mechanisms and structural roles in RNA recognition.

Revisiting the burden borne by fumarase: enzymatic hydration of an olefin

This study investigates the catalytic mechanism of class-I fumarate hydratase by analyzing structural and computational data from Methanocaldococcus jannaschii and Leishmania major enzymes.

Comparing algorithms for assessing upper limb use with inertial measurement units

This study compares methods for assessing upper limb use with IMUs, finding that intra-subject random forest machine learning outperforms other approaches.

Sequence-directed RNA remodeling within a topologically complex RNP substrate

The paper describes cryo-EM structures of 60S ribosomal intermediates, showing how DEAD-box ATPase Spb4 drives sequence-directed RNA remodeling during RNP assembly.

Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

The paper identifies reader proteins for 5-methylcytosine and its derivatives in C. elegans RNA using modified RNA baits and mass spectrometry.

MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

Structural basis for the hyperthermostability of an archaeal glutaminase induced by post-translational succinimide formation

This study investigates how succinimide formation in an archaeal glutaminase enhances thermostability through structural and computational analysis.

A Framework for Sensor-based Assessment of Upper-limb Functioning

This paper introduces a framework for assessing upper-limb functioning using sensors, including definitions, visualization methods, and new quantitative measures.

Estimating Movement Smoothness from Inertial Measurement Units

This paper evaluates the validity of using spectral arc length and log dimensionless jerk measures on IMU data for estimating movement smoothness, finding they are inappropriate for translational movements but applicable to rotational ones.

Specialisation and plasticity in a primitively social insect

The paper shows how a primitive social insect achieves both specialization and plasticity by integrating antagonistic processes across different scales.

Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification

This study identifies Pdap1 as a regulator of mature B cell survival and antibody gene diversification by modulating the integrated stress response and AID expression.

GWAS hints at pleiotropic roles for FLOWERING LOCUS T in flowering time and yield-related traits in canola

The paper identifies genetic associations and expression patterns of FT paralogs in canola, linking them to flowering time and yield-related traits through GWAS and QTL analyses.

Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection

This study shows that prophage induction, not phage particle production, is necessary for lethal disease in a microbiome-replete murine model of EHEC infection.

NOTCH-mediated non-cell autonomous regulation of chromatinstructure during senescence

This study shows NOTCH signaling modulates chromatin structure both autonomously and non-autonomously in senescent cells through the JAG1-NOTCH-HMGA1 axis.