B. Rozycki

Molecular mechanisms and energetics of lipid droplet formation and directional budding

This study uses simulations to show lipid droplet (LD) formation and budding are governed by ER and LD tensions, with budding being energetically neutral and tension-independent.

Coordination of transporter, cargo, and membrane properties during non-vesicular lipid transport.

The paper investigates how lipid transporters, cargo, and membrane properties coordinate during non-vesicular lipid transport in yeast.

Membrane curvature sensing by model biomolecular condensates

This study uses simulations to show that biomolecular condensates can sense membrane curvature by localizing at curved regions, suggesting a general mechanism for curvature sensing in processes like endocytosis.

Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates

The paper shows mechanical forces reduce T cell antigen discrimination by accelerating off-rates of higher-affinity antigens.

Cooperative Stabilization of Close-Contact Zones Leads to Sensitivity and Selectivity in T-Cell Recognition

The paper demonstrates that cooperative stabilization of close-contact zones in T-cell adhesion is sensitive to 1-3 foreign-peptide-MHC complexes and occurs at a sharp affinity threshold, implying selectivity in T-cell recognition.

Structural variability and concerted motions of the T cell receptor - CD3 complex

This study uses molecular dynamics simulations to analyze structural variability and motions of the TCR-CD3 complex, revealing tilt angles and coupled domain movements.

Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization

The paper investigates cohesin-dockerin interactions in cellulosomes, revealing two binding modes and an allosteric regulation mechanism via proline isomerization.