Author

D. W. Holden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

M. Liu· 2 shared A. E. Gallagher· 1 shared A. Predeus· 1 shared A. Typas· 1 shared B. M. Perez-Sepulveda· 1 shared C. Godlee· 1 shared C. M. Potel· 1 shared C. Vieitez· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

M. Liu

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3 papers

Recent·Most cited

Modulation of Salmonella virulence by a novel SPI-2 injectisome effector that interacts with the dystrophin-associated protein complex.

X.-J. Yu, H. X. Xie, Y. Li, M. Liu, R. Hou, A. Predeus, B. M. Perez-Sepulveda, J. Hinton, D. W. Holden, T. L. M. Thurston

This paper identifies a novel SPI-2 effector, SseM, in Salmonella that interacts with the dystrophin-associated protein complex and modulates bacterial growth in mice.

bioRxiv · Dec 7, 2023 · PreprintMicrobiology

The Salmonella transmembrane effector SteD hijacks AP1-mediated vesicular trafficking for delivery to antigen-loading MHCII compartments

C. Godlee, O. Cerny, M. Liu, S. Blundell, A. E. Gallagher, M. Shahin, D. W. Holden

This study identifies how SteD, a Salmonella effector, targets and traffics to MHCII compartments by hijacking AP1-mediated vesicular trafficking.

bioRxiv · Jan 10, 2022Microbiology

Global mapping of Salmonella enterica-host protein-protein interactions during infection

P. D. K. Walch, J. P. Selkrig, L. A. Knodler, M. Rettel, F. Stein, K. Fernandez, C. Vieitez, C. M. Potel, K. Scholzen, M. Geyer, K. Rottner, O. Steele-Mortimer, M. M. Savitski, D. W. Holden, A. Typas

The paper maps Salmonella enterica effector-host protein-protein interactions during infection, identifying 421 novel interactions and demonstrating their roles in pathogenesis.

bioRxiv · May 4, 2020Microbiology