M. M. Savitski

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

Emergence of community behaviors in the gut microbiota upon drug treatment

This study examines how drug treatment affects gut microbiota communities, finding that cross-protection is more common than cross-sensitization, and that metabolic processes contribute to these community behaviors.

High-throughput profiling of drug interactions in Gram-positive bacteria

This study systematically tests drug combinations in Gram-positive bacteria, identifying many new synergies and antagonisms, including effective combinations against drug-resistant strains.

Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins

The paper develops ppTPP to study mitochondrial dysfunction's effects on proteome stability and abundance, revealing group-specific response patterns in eukaryotic cells.

Rules for hardening influenza A virus liquid condensates

This study demonstrates that modulating transient interactions in influenza A virus condensates is more effective for hardening than temperature or concentration changes, offering a strategy for antiviral drug design.

Protein-Peptide Turnover Profiling reveals wiring of phosphorylation during protein maturation

The paper uses metabolic labeling and PTM-specific enrichment to reveal the temporal order of phosphorylation events during protein maturation, not protein stability.

Molecular mechanisms of stress-induced reactivation in mumps virus condensates

The paper investigates how cellular stress triggers reactivation of persistent mumps virus infection through molecular and structural changes in viral condensates.

Structure of the mycobacterial ESX-5 Type VII Secretion System hexameric pore complex

The paper presents a high-resolution cryo-EM structure of the ESX-5 Type VII secretion system hexameric pore complex, revealing its assembly and potential gating mechanisms.

Phage proteins block and trigger retron toxin/antitoxin systems

The paper identifies phage proteins that block or trigger retron toxin/antitoxin systems in bacteria, revealing their role in anti-phage defense.

Bacterial retrons encode tripartite toxin/antitoxin systems

The paper identifies retrons as a novel family of tripartite toxin/antitoxin systems in bacteria, with the reverse transcriptase and msDNA functioning as antitoxin components.

A dual-mechanism antibiotic targets Gram-negative bacteria and avoids drug resistance

This paper identifies a dual-mechanism antibiotic, SCH-79797, that kills Gram-negative and Gram-positive bacteria with low resistance and outperforms combination treatments.

Global mapping of Salmonella enterica-host protein-protein interactions during infection

The paper maps Salmonella enterica effector-host protein-protein interactions during infection, identifying 421 novel interactions and demonstrating their roles in pathogenesis.

The outer membrane lipoprotein NlpI nucleates hydrolases within peptidoglycan multi-enzyme complexes in Escherichia coli

This study identifies NlpI as a scaffold for PG hydrolases in E. coli, forming multi-enzyme complexes that coordinate PG synthesis and hydrolase activity.

Proteome thermal stability reflects organ physiology and identifies drug-target engagement in vivo

This study introduces tissue-TPP and blood-CETSA to measure proteome thermal stability, revealing organ physiology and drug-target engagement in vivo.

Effect of Sec61 interaction with Mpd1 on Endoplasmic Reticulum-Associated Degradation

The paper identifies Mpd1 as an ERAD factor that interacts with Sec61 and shows that this interaction is required for CPY* ERAD.