Protein crosslinking as a therapeutic strategy for SOD1-related ALS
Md Amin Hossain, Richa Sarin, Daniel P. Donnelly, Brandon C. Miller, Joseph Peter Salisbury, Jeremy B. Conway, Samantha Watson, Jenifer N. Winters, Novera Alam, Durgalakshmi Sivasankar, Aparna C. Ponmudiyan, Tanvi Gawde, Sunanda Kannapadi, Jared R. Auclair, Lee Makowski, , Jeffrey N. Agar
This paper demonstrates that a cyclic thiosulfinate cross-linker stabilizes SOD1 variants in vivo, showing efficacy and low toxicity for treating SOD1-related ALS.
bioRxiv · Jun 23, 2021 · PreprintNeuroscience