Lee Makowski

The paper identifies rare bioactive tau oligomers in Alzheimer's brain that can induce templated misfolding and fibril formation, distinguishing them from non-bioactive oligomers.

This paper uses micro-XRD and XRF to analyze tau aggregates in Pick's disease, finding distinct elemental compositions and fibril structures in different lesion types.

This paper demonstrates that a cyclic thiosulfinate cross-linker stabilizes SOD1 variants in vivo, showing efficacy and low toxicity for treating SOD1-related ALS.

This study uses in situ SAXS to analyze the molecular structure of Aβ and tau protein deposits in Alzheimer's disease brain tissue, revealing structural differences and coalescence patterns.