DHRS7 Integrates NADP+/NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid Pathway
Yanan Ma, King Lam Hui, Yohannes Abere Ambaw, Tobias C. Walther, Robert V. Farese, Miklos Lengyel, Zaza Gelashvili, Dajun Lu, Philipp Niethammer
This study identifies DHRS7 as a redox sensor that converts NADP+/NADPH balance into inflammatory lipid signals via the oxoeicosanoid pathway, with implications for immune response and therapeutic targeting.
bioRxiv · Feb 5, 2025 · PreprintImmunology