Yohannes Abere Ambaw

The paper identifies shared lipid and proteomic alterations in frontotemporal lobar degeneration and Alzheimer's disease, with greater changes in FTLD frontal cortex.

The paper identifies adaptive pathways in hepatocytes that restore homeostasis during lipid overload by coordinating fatty acid oxidation and suppression of unsaturated fatty acid synthesis.

The paper develops a human stem cell toolkit for studying lysosomal storage disorders by generating proteomic data from induced cortical and dopaminergic-like neurons.

LipidCruncher processes, visualizes, and analyzes lipidomic data with quality controls, enabling efficient and rigorous analysis of lipid profiles.

The paper identifies plasma lipidome changes in FTD carriers, finding specific lipid alterations linked to genetic subtypes and disease severity.

The paper demonstrates that the lipid droplet assembly complex (LDAC) catalyzes oil-phase formation in membranes, enabling organized lipid droplet formation.

This study identifies DHRS7 as a redox sensor that converts NADP+/NADPH balance into inflammatory lipid signals via the oxoeicosanoid pathway, with implications for immune response and therapeutic targeting.

This study identifies PLD3 and PLD4 as enzymes synthesizing S,S-BMP, a lysosomal phospholipid critical for lipid degradation and brain health.

Blocking the carboxy terminus of progranulin enhances gene therapy efficacy in progranulin-deficient mice by reducing sortilin interactions and improving biomarker outcomes.