Robert V. Farese

The paper determines how MBOAT1 remodels phosphatidylserine by solving its cryo-EM structures and combining them with lipidomics and simulations.

The paper identifies shared lipid and proteomic alterations in frontotemporal lobar degeneration and Alzheimer's disease, with greater changes in FTLD frontal cortex.

The paper identifies adaptive pathways in hepatocytes that restore homeostasis during lipid overload by coordinating fatty acid oxidation and suppression of unsaturated fatty acid synthesis.

The paper develops a human stem cell toolkit for studying lysosomal storage disorders by generating proteomic data from induced cortical and dopaminergic-like neurons.

LipidCruncher processes, visualizes, and analyzes lipidomic data with quality controls, enabling efficient and rigorous analysis of lipid profiles.

The paper shows that LD-targeted proteins are confined by nanodomains and transported via ER-LD bridges, revealing mechanisms for their selective accumulation on lipid droplets.

The paper identifies a STING-IFN-CH25H lipid axis linking innate immune activation to tau pathology and shows its role in neurodegeneration.

The paper identifies plasma lipidome changes in FTD carriers, finding specific lipid alterations linked to genetic subtypes and disease severity.

The paper demonstrates that the lipid droplet assembly complex (LDAC) catalyzes oil-phase formation in membranes, enabling organized lipid droplet formation.

This study identifies DHRS7 as a redox sensor that converts NADP+/NADPH balance into inflammatory lipid signals via the oxoeicosanoid pathway, with implications for immune response and therapeutic targeting.

This study identifies PLD3 and PLD4 as enzymes synthesizing S,S-BMP, a lysosomal phospholipid critical for lipid degradation and brain health.

Blocking the carboxy terminus of progranulin enhances gene therapy efficacy in progranulin-deficient mice by reducing sortilin interactions and improving biomarker outcomes.

The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.

This paper reports the structure of yeast seipin, revealing a decameric cage that facilitates lipid droplet formation through conformational changes.

The paper introduces the Lipid Droplet Knowledge Portal, a resource integrating datasets on lipid droplet biology to uncover new determinants of lipid storage.

The paper presents a systematic protein turnover map for S. cerevisiae, revealing degradation pathways and novel regulatory nodes for lipid metabolism.

This study identifies FIT2 as a lipid phosphate phosphatase essential for maintaining endoplasmic reticulum structure and lipid homeostasis.