Dale Shuman

Modeling Insights into Potential Mechanisms of Opioid-Induced Respiratory Depression within Medullary and Pontine Networks

The paper uses a computational model to test how opioids affect synaptic excitability in medullary and pontine networks, suggesting selective synaptic actions may explain breathing mechanics changes in opioid-induced respiratory depression.

Hypoxia evokes a sequence of raphe-pontomedullary network operations for inspiratory drive amplification and gasping

The paper investigates how hypoxia triggers gasping through neural network reconfiguration in the brainstem, showing disinhibition and coordinated activity in respiratory circuits.