The Influence of Macrophages within the Tumor Microenvironment on Ovarian Cancer Growth and Response to Therapies
Parisa Nikeghbal, Danielle Burke, Dalet Armijo, S Aldarondo-Quiñones, Diane S. Lidke, Mara P. Steinkamp
This study shows that M2 macrophages in the tumor microenvironment enhance ovarian cancer growth and reduce sensitivity to paclitaxel, and that targeting TAMs with CSF-1R inhibitors can improve treatment outcomes when combined with chemotherapy.
bioRxiv · Jan 29, 2025 · PreprintCancer Biology