Deep transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis
Szabolcs Takács, Katalin Skrapits, Balázs Göcz, Éva Rumpler, Miklós Sárvári, Barbara Göblyös, Dalma Biri, Szilárd Póliska, Gergely Rácz, András Matolcsy, Erik Hrabovszky
The paper develops and validates an IHC/LCM-Seq method to profile transcriptomes of AgRP and POMC neurons in human hypothalamus, revealing distinct gene expression patterns and potential pharmacological targets for weight management.
Nature Communications · Aug 15, 2026Peer-reviewedNeuroscience