Szilárd Póliska

The paper develops and validates an IHC/LCM-Seq method to profile transcriptomes of AgRP and POMC neurons in human hypothalamus, revealing distinct gene expression patterns and potential pharmacological targets for weight management.

This study shows that fedratinib, a ThTr2 and JAK2 inhibitor, suppresses thermogenic activation in human adipocytes by reducing amino acid consumption and thermogenic gene expression.

This study shows that peripheral monocytes' epigenomic landscape is rewired by a distal tumor, shaping their transcriptional response upon tumor infiltration.

The paper analyzes commercial Saccharomyces cerevisiae baker's yeasts, revealing strain redundancy, genome plasticity, and limited colonization of human niches compared to commercial strains.

The paper shows that ID1 and ID3 upregulation is crucial for thermogenic response in human adipocytes under adrenergic stimulation.

The paper identifies estrogen-regulated peptidergic neurons in the lateral septum that project to gonadotropin-releasing hormone neurons and reveals their unique transcriptome and potential evolutionary conservation.

The paper develops an LCM-Seq method for spatial transcriptomics of fluorescently-tagged cholinergic neurons in mice, achieving deep transcriptome profiling with high accuracy.

This study examines the temporal transcriptomic changes during in vitro chondrogenesis using RNA sequencing and identifies key transcription factors involved in cartilage formation.