MDA5 and the integrated stress response control sex-specific type 1 diabetes onset in NOD mice
Erik S. Van Dis, Alessandra T DeGidio, Lara Yao, Damion Winship, Carmela Sidrauski, Jacquelyn A. Gorman, Daniel B. Stetson
This study shows that MDA5 and the integrated stress response influence sex-specific type 1 diabetes onset in NOD mice, with MDA5 haploinsufficiency protecting males but not females.
bioRxiv · Jul 7, 2026 · PreprintImmunology