Jacquelyn A. Gorman

This study shows that endothelial origin, not inflammatory stimulus, primarily determines transcriptional and functional responses to LPS and IL-6/IL-6R.

This study shows that MDA5 and the integrated stress response influence sex-specific type 1 diabetes onset in NOD mice, with MDA5 haploinsufficiency protecting males but not females.

This study shows the IFIH1-A946T risk variant increases T1D risk in females but not males by enhancing IFN I signaling and altering immune cell profiles in NOD mice.