Carmela Sidrauski

MDA5 and the integrated stress response control sex-specific type 1 diabetes onset in NOD mice

This study shows that MDA5 and the integrated stress response influence sex-specific type 1 diabetes onset in NOD mice, with MDA5 haploinsufficiency protecting males but not females.

eIF2B Activator Rescues Neonatal Lethality of an eIF2Bα Sugar Phosphate Binding Mutation Associated with Vanishing White Matter Disease

This paper shows that an eIF2B activator rescues neonatal lethality in a VWM mouse model but leads to age-related motor deficits and myelin loss.

GDF15 is a dynamic biomarker of the Integrated Stress Response in the central nervous system

This study identifies GDF15 as a biomarker of the Integrated Stress Response in the CNS, showing its correlation with ISR activity in both animal models and human patients.

Precise Estimation of In Vivo Protein Turnover Rates

This paper introduces a new framework to estimate in vivo protein turnover rates by addressing labeling identification and amino acid enrichment challenges, revealing differences in protein turnover between mice and naked mole-rats.

eIF2B activator prevents neurological defects caused by a chronic Integrated Stress Response

The paper shows that a novel eIF2B activator prevents neurological defects in a mouse model of Vanishing White Matter disease by normalizing the transcriptome and proteome.