Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female Mice
Cellas A. Hayes, Erik L. Hodges, Jessica P. S. Marshall, Sreemathi Logan, Julie A. Farley, Daniel B. Owens, William Edmund Sonntag, Nicole M. Ashpole
This study shows that reducing IGF-1R in adult hippocampal neurons impairs spatial learning and memory in male mice but not females, with structural changes in dendritic boutons and altered signaling pathways.
bioRxiv · Aug 8, 2021 · PreprintNeuroscience