Macrophage immunosenescence prolongs intraocular inflammation in aged mice via impaired induction of regulatory T cells
Taku Yamamoto, Keitaro Hase, Joseph B. Lin, Shinobu Yamaguchi, Norihiko Misawa, Jiayi Li, Kenta Kato, Ryo Terao, Brian S. Sohn, Daniel Du, Mitsukuni Yoshida, Charles W. Pfeifer, Tae Jun Lee, Jason J. Colasanti, Andrea C. Santeford, , Rajendra S. Apte
This study shows that aging impairs macrophage-induced regulatory T cells in mice, leading to chronic uveitis by linking immunosenescence to persistent inflammation.
bioRxiv · Jan 20, 2026 · PreprintImmunology