Rajendra S. Apte

In a mouse branch retinal vein occlusion model, retinal ganglion cells die progressively over 14 days. α-RGCs and F-RGCs are lost fastest, and TBR2-positive intrinsically photosensitive RGCs survive best.

This study identifies miR-34a's role in promoting pathological angiogenesis in AMD by suppressing KLF2 and upregulating CXCR4/CXCL12.

This study examines retinal and vascular abnormalities in mouse models with CRX homeodomain mutations, finding disrupted photoreceptor differentiation and retinal rosettes that affect inner neuron localization and vasculature.

This study shows that aging impairs macrophage-induced regulatory T cells in mice, leading to chronic uveitis by linking immunosenescence to persistent inflammation.

This study shows that SARM1 depletion prevents NMNAT1-dependent photoreceptor death and retinal degeneration in mice, identifying SARM1 as a therapeutic target for retinopathies.